Also known as interstitial cystitis, Painful Bladder Syndrome occurs when the bladder develops a an urgent and painful tendency to relieve itself excessively, leading to increased episodes of urination. This is accompanied with pelvic pain.While the exact cause of this disease is not known, correlation has been found between bladder defects, allergies, blood vessel defects and mast cell abnormalities. Painful bladder syndrome has a tendency to develop gradually and stay for a long period of time. This gives it the classification of a chronic disease. It is more prevalent in women and has the potential of considerably affecting the quality of life.