AKUH Participates in Global Clinical Trial for Potential Treatment for COVID Associated Pneumonia

Today, Roche Kenya Ltd. announced that patients in Kenya have enrolled in its EMPACTA clinical trial at the Clinical Research Unit of Aga Khan University Hospital Nairobi.

The EMPACTA study is a global Phase III clinical trial. It is a randomized, double-blind, placebo-controlled and multicenter study that will evaluate the efficacy and safety of Roche’s medicine Actemra (tocilizumab) in the treatment of COVID-19 associated hospitalised pneumonia.

Both public and private sector patients in Kenya were eligible to participate in the trial if they met the study criteria which is being run at Aga Khan University Hospital Nairobi.

“This is a watershed moment for Kenya and us at the Aga Khan University Hospital, Nairobi, that we can participate in an international clinical trial that is testing the effectiveness of this novel drug on our patients here,” said Dr. Reena Shah, Associate Professor of Medicine in Infectious Diseases, and the Principal Investigator of the study in Kenya. "This is where we contribute knowledge and experience about our  capability and the outcome of our patients to the international community."

“The COVID-19 pandemic continues to evolve rapidly in Kenya and around the world and Roche is doing everything we can to contribute. Our people are working day and night with the aim of developing, manufacturing and supplying key tests and medicines where they are needed most. We are so glad to see Kenyan patients on the EMPACTA trial," said Dr. Beatrice Nyawira, Medical Director, Roche Kenya Ltd.

“Disparities and lack of diversity in medical research holds the global community back, and Roche Kenya is proud to help close this gap.”

Comments by Dr. Rashid A. Aman, the Chief Administrative Secretary in the Kenya Ministry of Health

The Ministry of Health remains committed to providing the highest standard of health to all Kenyans and supporting the exploration of new therapeutic solutions. This could not be more important and timely than this period of the COVID 19 pandemic. In this regard the Ministry is supporting and participating in several global clinical trials aimed at discoveries of therapeutic agents and vaccines against Covid19.

Which is why the Ministry lends its support to the global trial on the use of tocilizumab in COVID-19 patients with moderate disease (EMPACTA trial) being conducted at the Aga Khan University Hospital here in Kenya as one of the study sites. We commend our private sector partners the Aga Khan University Hospital and Roche Kenya in bringing this study to Kenya.

The merit of this ongoing trial has recently been validated by the recent finding by a team of clinical researchers at the University of Michigan that demonstrated that in a controlled study of 154 patients with severe COVID-19 illness requiring mechanical ventilation, tocilizumab was associated with a 45% reduction in the hazard of death, despite twice the frequency of superinfection  

The COIVD 19 pandemic can only be overcome through a multi-sectoral, multi-stakeholder engagement that brings together academia, research, government and the private sector. The Ministry of Health remains committed to the advancement of relevant, inclusive and ethical research that complies with all national regulations.