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Hardening of the Arteries (Atherosclerosis)

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Hardening of the arteries occurs when fatty deposits called plaque (made up of cholesterol, fat, and other materials) build up inside the arteries.  

As plaque builds up, the arteries become narrower and less flexible, reducing blood flow to important parts such as the heart, brain, and legs. Over time, this can lead to serious health problems, including: 

  • Coronary artery disease, which can cause angina (chest pain) or a heart attack  

  • Stroke, when blood flow to the brain is interrupted  

  • Peripheral artery disease (PAD), which reduces blood flow to the legs  

Sometimes, a plaque can suddenly rupture, causing a blood clot to form. This may completely block blood flow and result in a heart attack or stroke.

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Disclaimer:

The information provided on our website is for educational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare professional for advice regarding your individual health and medical needs.

Compiled by the AKU Medical College Center for Clinical Best Practices

Last Updated: June 2026

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