​Hypophosphatasia

Hypophosphatasia is a genetic disorder which affects bone and teeth development in children. It is a congenital disorder, meaning that it exists at birth and your child may be born with it. It is also a genetic disorder, and can be inherited from an affected parent (Autosomal Dominant) or when both parents are asymptomatic carriers (Autosomal Recessive).

Hypophosphatasia occurs due to problems with mineralization, which is a process by which the bones absorb calcium and phosphorus – important minerals for making bones and teeth strong and hard. Due to interference with mineralization, the bones and teeth are softer and the child is more prone to bone deformities, fractures and tooth loss.