​Myeloablative Total Body Irradiation (TBI)

Myeloablative Total Body Irradiation (TBI) is a specialized radiation therapy used as part of the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in patients with leukemia and other blood cancers and disorders. TBI delivers radiation to the entire body, targeting both cancerous cells and the bone marrow, to prepare the body for the transplant. The therapy is carefully planned to ensure accurate dosing and safe delivery. Depending on the patient's age, disease, and transplant type, various dose and fractionation schedules are used.

Since TBI involves irradiating the entire body, precautions are taken to protect critical organs and limit side effects. Myeloablative TBI is typically administered over several days to reduce toxicity and allow for precise treatment.

Conditions We Treat

  • Aplastic anaemia (inability of bone marrow to produce blood cells)
  • Thalassemia major (genetic blood disorder)
  • Leukemia (cancer of the blood and bone marrow)
  • Lymphoma (cancer of the lymphatic system)
  • Other blood and bone marrow disorders​​​

Our Treatment Approach

AKUH provides a comprehensive range of services to ensure the highest standard of care for patients undergoing myeloablative TBI:​

  • Consultation and diagnosis: Our team of radiation oncologists and transplant specialists work together to assess your condition and determine the appropriate TBI regimen.
  • Treatment planning: A personalized treatment plan is developed using CT scans and advanced technology to calculate the radiation dose for different body areas. Immobilization devices are used to ensure accuracy during treatment.
  • Advanced technology: We utilize LINAC machines to deliver precise radiation doses, ensuring patient safety and treatment efficacy.
  • Supportive care: Our team monitors your condition throughout the treatment process, managing any side effects and ensuring your comfort.​

Our Multidisciplinary Team

Your care at AKUH is overseen by a highly experienced team of specialists, including:

  • Transplant Physician: Experts in managing systemic treatment as part of the transplant process.
  • Radiation Oncologists: Physicians specializing in the use of radiation therapy for cancer treatment.
  • Radiation Technologists: Professionals who operate the radiation therapy machines and deliver your treatment.
  • Clinical Medical Physicists: Experts ensuring precise treatment planning and quality assurance for safe radiation therapy delivery.
  • Nurses: Specially trained nurses provide care and support throughout your treatment.

To learn more about our highly trained and skilled experts, search on Find a Doctor under the speciality of Radiation Oncology​.  

If you have been diagnosed with cancer and are considering stem cell transplant, contact AKUH to learn more about Myeloablative Total Body Irradiation (TBI) and discuss your treatment options with our team.


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